Stem Cell Research

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Scientists used Stereo-seq to study axolotl brain regeneration. They found ependymoglial cells at the injury site that can transition into neuron-like cells, similar to neurogenesis. They also discovered spatially defined neurons that regress to an immature state. This research sheds light on brain regeneration mechanisms in vertebrates.

Researchers developed a deep learning model to predict neural stem cell (NSC) differentiation, showing impressive accuracy using only bright field images. The model demonstrated robustness across various inducers, including nanoparticles, promising to accelerate NSC applications.

Scientists explore base editing using A3A (N57Q)-BE3 for engrafting hematopoietic stem cells (HSCs). They achieve precise edits at the BCL11A enhancer, preventing sickling in sickle cell disease and β-thalassemia. Multiplex editing and HbF induction are also demonstrated in self-renewing HSCs. Base editing shows potential for therapeutic genome modification in HSPCs.

This report provides an extensive review of recent clinical trials in stem cell research, emphasizing various collaborations, particularly those between CytoMed & MD Anderson Center and Life Edit & Novo Nordisk. It also covers business growth, research advancements, and financial updates from leading companies such as Seres Therapeutics, ElevateBio, Ensoma, and Krystal Biotech.